Dose-painting IMRT optimization using biological parameters
نویسندگان
چکیده
منابع مشابه
On the role of modeling parameters in IMRT plan optimization.
The formulation of optimization problems in intensity-modulated radiotherapy (IMRT) planning comprises the choice of various values such as function-specific parameters or constraint bounds. In current inverse planning programs that yield a single treatment plan for each optimization, it is often unclear how strongly these modeling parameters affect the resulting plan. This work investigates th...
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PURPOSE Implantable devices routinely used for increasing spatial accuracy in modern image-guided radiation treatments (IGRT), such as fiducials or brachytherapy spacers, encompass the potential for in situ release of biologically active drugs, providing an opportunity to enhance the therapeutic ratio. We model this new approach for two types of treatment. METHODS AND MATERIALS Radiopaque fid...
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The treatment planning software TRiP98 [1, 2, 3] is successfully used in the ion therapy project at GSI. A crucial part of the treatment planning is the particle number optimization in order to achieve a target dose distribution as close as possible to the prescribed biological dose distribution. The optimization task can be expressed mathematically by the minimization of a multidimensional obj...
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Treatment planning for intensity modulated radiation therapy (IMRT) is challenging due to both the size of the computational problems (thousands of variables and constraints) and the multi-objective, imprecise nature of the goals. We apply hierarchical programming to IMRT treatment planning. In this formulation, treatment planning goals/objectives are ordered in an absolute hierarchy, and the p...
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ID: 17988 Title: Improve PTV Dose Distribution by Using Spatial Information in IMRT Optimization Purpose: The spatial distribution of radiation dose within the PTV does have clinical significance. For instance, if hot/cold spots in the PTV cannot be avoided, high doses are preferred to be located in the center, and low doses at the peripheries. However, traditional plan optimization models for ...
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ژورنال
عنوان ژورنال: Acta Oncologica
سال: 2010
ISSN: 0284-186X,1651-226X
DOI: 10.3109/02841861003767539